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3/5 Moderate evidence

Bone health evidence brief

Vitamin K2

Vitamin K2 has plausible bone and calcification roles, but supplementation claims are strongest in deficiency-risk or osteoporosis contexts, not general longevity use.

Context-dependent bone support health / longevity 6 linked sources Content audit 2026-05-05

Headline Finding

RCT meta-analyses report bone-marker and some fracture signals, while cardiovascular calcification trials remain inconsistent.

Dose Context

Studies use different menaquinone forms and doses; food intake, vitamin D, calcium, anticoagulant use, and baseline risk all change the interpretation.

Important Caveat

People using warfarin or other vitamin K-sensitive anticoagulants should not change vitamin K intake without clinical supervision.

Source Drawer

Linked Research

6 papers and evidence links - audit 2026-05-05
  1. Review NIH ODS vitamin K fact sheet
  2. Meta-analysis Adult bone meta-analysis
  3. Meta-analysis K2 osteoporosis meta-analysis
  4. Review K2 postmenopausal osteoporosis review
  5. Meta-analysis Vascular calcification meta-analysis
  6. Trial Cardiovascular trial review

How To Read This Rating

The score reflects evidence that the supplement does its stated job. Some jobs are direct, such as strength, endurance, or recovery; others are indirect, such as sleep, mood, appetite, or health support. A real effect can still receive a cautious practical rating when dose, safety, product quality, or audience fit remain uncertain.

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