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2.5/5 Weak evidence

Liver health evidence brief

Milk thistle

Milk thistle and silymarin have mixed liver-disease research and do not support broad liver detox claims.

Weak for broad liver claims health 6 linked sources Content audit 2026-05-05

Headline Finding

NCCIH notes liver-disease trials are conflicting or too limited; NAFLD meta-analyses show marker signals but not decisive clinical outcomes.

Dose Context

Studies use specific silymarin extracts and doses; generic detox blends do not map cleanly to the research.

Important Caveat

Liver disease, abnormal liver enzymes, hepatitis, alcohol-related disease, and medication toxicity require clinical evaluation, not self-treatment.

Source Drawer

Linked Research

6 papers and evidence links - audit 2026-05-05
  1. Review NCCIH milk thistle overview
  2. Meta-analysis Liver disease meta-analysis
  3. Meta-analysis MASLD/NAFLD meta-analysis
  4. Trial NASH randomized trial
  5. Review Cochrane liver disease review
  6. Review Hepatitis C DARE review

How To Read This Rating

The score reflects evidence that the supplement does its stated job. Some jobs are direct, such as strength, endurance, or recovery; others are indirect, such as sleep, mood, appetite, or health support. A real effect can still receive a cautious practical rating when dose, safety, product quality, or audience fit remain uncertain.

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