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2.5/5 Weak evidence

Sleep support evidence brief

L-ornithine

L-ornithine is an amino acid involved in the urea cycle. Supplements are commonly used for fatigue, ammonia clearance, sleep quality, and recovery claims.

Small trials suggest fatigue, stress, or sleep effects, but evidence is not strong enough for broad fatigue-management claims.

Fatigue/sleep signal narrow Potentially promising sleep / health 6 linked sources Content audit 2026-05-16

Headline Finding

Small RCTs report fatigue or stress/sleep signals; ammonia-clearing claims need stronger replication.

Dose Context

Human studies use different hydrochloride or free-form protocols; stress/sleep findings do not automatically generalize to other outcomes.

Important Caveat

Ammonia-clearing endurance claims need stronger performance data before being treated as a separate use case.

Source Drawer

Linked Research

6 papers and evidence links - audit 2026-05-16
  1. Trial Physical fatigue RCT
  2. Trial Stress/sleep RCT full text
  3. Trial Stress/sleep RCT
  4. Trial Exercise/ammonia trial
  5. Trial Mental stress RCT
  6. Review Ornithine-alpha-ketoglutarate review

How To Read This Rating

The score reflects evidence that the supplement does its stated job. Some jobs are direct, such as strength, endurance, or recovery; others are indirect, such as sleep, mood, appetite, or health support. A real effect can still receive a cautious practical rating when dose, safety, product quality, or audience fit remain uncertain.

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