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2/5 Weak evidence

Recovery evidence brief

HICA / KIC

HICA and KIC are sold as anti-catabolic leucine metabolites, but human sport evidence is sparse, small, and not strong enough for muscle-gain marketing.

Leucine-metabolite evidence thin recovery / hypertrophy / strength 5 linked sources Content audit 2026-05-04

Headline Finding

Small HICA/KIC trials exist; evidence is too sparse for anti-catabolic or muscle-gain claims.

Dose Context

HICA and KIC are distinct compounds. HMB, leucine, and GAKIC claims do not automatically apply to plain HICA/KIC products.

Important Caveat

Body-composition or recovery benefits need independent athlete trials with product-matched dosing.

Source Drawer

Linked Research

5 papers and evidence links - audit 2026-05-04
  1. Trial HICA athlete trial
  2. Review HICA full article
  3. Trial KIC exercise RCT
  4. Review KIC PubMed record
  5. Trial HMB/KIC EIMD trial

How To Read This Rating

The score reflects evidence that the supplement does its stated job. Some jobs are direct, such as strength, endurance, or recovery; others are indirect, such as sleep, mood, appetite, or health support. A real effect can still receive a cautious practical rating when dose, safety, product quality, or audience fit remain uncertain.

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