Urinary health evidence brief
D-mannose is a simple sugar sold for urinary tract support, especially recurrent UTI prevention. It is not a treatment for an active infection.
D-mannose is popular for recurrent UTI prevention, but newer controlled evidence does not support confident routine use.
2024 JAMA RCT: daily D-mannose did not reduce medically attended recurrent UTIs compared with placebo in women with recurrent UTI.
Older studies used gram-level powder protocols, but current evidence is too uncertain to recommend a standard preventive dose.
It does not treat an active UTI. Delaying proper diagnosis or antibiotics when needed can be harmful.
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