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2/5 Weak evidence

Urinary health evidence brief

D-mannose

D-mannose is popular for recurrent UTI prevention, but newer controlled evidence does not support confident routine use.

Weak for recurrent UTI prevention health 6 linked sources Content audit 2026-05-05

Headline Finding

2024 JAMA RCT: daily D-mannose did not reduce medically attended recurrent UTIs compared with placebo in women with recurrent UTI.

Dose Context

Older studies used gram-level powder protocols, but current evidence is too uncertain to recommend a standard preventive dose.

Important Caveat

It does not treat an active UTI. Delaying proper diagnosis or antibiotics when needed can be harmful.

Source Drawer

Linked Research

6 papers and evidence links - audit 2026-05-05
  1. Trial 2024 JAMA RCT
  2. Review Cochrane review PubMed
  3. Full text Cochrane review full text
  4. Meta-analysis 2025 RCT meta-analysis
  5. Meta-analysis Earlier recurrent UTI meta-analysis
  6. Review D-mannose narrative review

How To Read This Rating

The score reflects evidence that the supplement does its stated job. Some jobs are direct, such as strength, endurance, or recovery; others are indirect, such as sleep, mood, appetite, or health support. A real effect can still receive a cautious practical rating when dose, safety, product quality, or audience fit remain uncertain.

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