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2/5 Weak evidence

Joint support evidence brief

Cissus quadrangularis

Human evidence is mostly in joint pain, obesity, fracture, or bone-marker contexts rather than healthy lifter performance or injury prevention.

Clinical evidence, weak gym case health / recovery 6 linked sources Content audit 2026-05-04

Headline Finding

Clinical and pilot data exist, but athlete-specific injury-prevention or tendon-repair evidence is not established.

Dose Context

Extracts, ketosteroid standardization, and blended products differ materially, so one preparation does not validate another.

Important Caveat

Joint-repair and tendon-protection claims need stronger athlete-specific randomized evidence and clearer product identity.

Source Drawer

Linked Research

6 papers and evidence links - audit 2026-05-04
  1. Safety Safety and efficacy review
  2. Meta-analysis Bone-marker meta-analysis
  3. Review Exercise-trained joint pain pilot
  4. Trial Obesity RCT full text
  5. Trial Central obesity RCT
  6. Trial Fracture healing trial

How To Read This Rating

The score reflects evidence that the supplement does its stated job. Some jobs are direct, such as strength, endurance, or recovery; others are indirect, such as sleep, mood, appetite, or health support. A real effect can still receive a cautious practical rating when dose, safety, product quality, or audience fit remain uncertain.

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